Gclm Null Mice have Drastically Increased Angiogenic Potential
نویسندگان
چکیده
منابع مشابه
Metallothionein null cells have increased sensitivity to anticancer drugs.
Overexpression of metallothioneins (MTs) protects some cells against heavy metals, mutagens, anticancer agents, and reactive oxygen species. We have examined the effect of the loss of MT expression on the cytotoxicity of anticancer agents and mutagens using embryonic fibroblast cells from transgenic mice with targeted disruptions of MT I and II genes (MT -/-). MT -/- cells expressed no detectab...
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Overexpression of metallothioneins (MTs) protects some cells against heavy metals, mutagens, anticancer agents, and reactive oxygen species. We have examined the effect of the loss of Ml expression on the cytotoxicity of anticancer agents and mutagens using embryonic fibroblast cells from transgenic mice with targeted disruptions of A/7 / and // genes (MT —/—). MT —/— cells expressed no...
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McKusick-Kaufman syndrome (MKS) is an autosomal recessive disorder characterized by post-axial polydactyly, congenital heart defects and hydrometrocolpos, a congenital structural abnormality of female genitalia. Mutations in the MKKS gene have also been shown to cause some cases of Bardet-Biedl syndrome (BBS) which is characterized by obesity, pigmentary retinopathy, polydactyly, renal abnormal...
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Cassana M. Littler,1 Kenneth G. Morris, Jr.,1 Karen A. Fagan,1 Ivan F. McMurtry,1 Robert O. Messing,3 and Edward C. Dempsey1,2 1Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, and 2Denver Veterans Administration Medical Center, Denver, Colorado 80262; and 3Ernest Gallo Clinic and Research Center, Department of Neurology, University of California San ...
متن کاملIncreased eNO and pulmonary iNOS expression in eNOS null mice.
Nitric oxide (NO) is a major regulatory molecule of the cardiovascular system; however, measurement of vascular NO synthesis in vivo represents a major challenge. NO stemming from the lower respiratory tract has been used as a marker of vascular endothelial function. Experimental evidence for this concept is lacking. Therefore, the aim of the present study was to investigate this relationship. ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.592.12